Modulatory effects of Ginkgo biloba in Lead induced Genetic Damage in Somatic Cells of Mice.

Abstract

The effects of Ginkgo biloba on lead nitrateinduced
clastogenicity in mouse bone marrow
cells were investigated in this work. In the first
experiment, mice were given different doses of
Ginkgo biloba extract (200, 400, 600 mg/kg body
weight), the proportion of chromosomal
abnormalities was measured, and the statistical
analysis revealed that the results were
inconsequential. The results revealed that the
plant extract is antimutagenic. In the second
experiment, animals were administered Ginkgo
biloba extract for seven days and then given lead
nitrate one day before being scarified. In
40mg/kg body weight lead nitrate treated
animals, the percentage of chromosomal
abnormalities increased significantly. However,
when mice were co-administered with Ginkgo
biloba extract for seven days prior to the
priming experiment, the frequency of
chromosomal abnormalities decreased. Thus, the
findings clearly show that Ginkgo biloba extract
protects mice somatic cells against lead nitrateinduced
cytogenetic damage.