Early Alzheimer’s Diagnosis Using Neural Networks

Authors

  • Ms. Jataboina Hoyala Assistant Professor, Dept. of CSE-AIML, Lords Institute of Engineering and Technology Author
  • Mr. Syed Khaja Fareeduddin B.E Student Dept. of CSE-AIML, Lords Institute of Engineering and Technology Author
  • Mr. Md Obaidur Rahman Akbar B.E Student Dept. of CSE-AIML, Lords Institute of Engineering and Technology Author

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects millions worldwide, with early diagnosis being crucial for effective intervention. Traditional diagnostic methods are often time-consuming and prone to subjectivity, necessitating automated approaches for improved accuracy and efficiency. This project proposes a deep learning-based framework for early Alzheimer’s detection using a ResNet (Residual Network) model trained on MRI and PET brain scan images. The ResNet architecture is chosen for its ability to learn deep hierarchical features while mitigating vanishing gradient issues, enabling robust classification of Alzheimer’s stages. The dataset is preprocessed to enhance image quality, and the model is trained and evaluated using standard metrics such as accuracy, sensitivity, and specificity. Experimental results demonstrate the potential of deep learning in achieving high diagnostic accuracy, aiding clinicians in early detection and intervention. This work contributes to advancing AI-driven medical diagnostics, offering a scalable and reliable solution for Alzheimer’s screening. 

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References

1. Nguyen, M.; He, T.; An, L.; Alexander, D.C.;

Feng, J.; Yeo, B.T. Predicting Alzheimer’s disease

progression using deep recurrent neural networks.

Neuro Image 2020, 222, 117203. [Cross Ref]

2. Jung, W.; Jun, E.; Suk, H.-I.; Alzheimer’s

Disease Neuroimaging Initiative. Deep recurrent

model for individualized prediction of Alzheimer’s disease progression. Neuro Image 2021, 237,

118143. [Cross Ref].

3. Liang, W.; Zhang, K.; Cao, P.; Liu, X.; Yang,

J.; Zaiane, O. Rethinking modeling Alzheimer’s

disease progression from a multi-task learning

perspective with deep recurrent neural network.

Comput. Biol. Med. 2021, 138, 104935 [Cross

Ref].

4. Lin, K.; Jie, B.; Dong, P.; Ding, X.; Bian, W.;

Liu, M. Convolutional recurrent neural network for

dynamic functional MRI analysis and brain disease

identification. Front. Neurosci. 2022, 16, 933660.

[Cross Ref]

5. Bowles, C.; Gunn, R.; Hammers, A.; Rueckert,

D. Modelling the progression of Alzheimer’s

disease in MRI using generative adversarial

networks. In Medical Imaging 2018: Image

Processing; SPIE: Houston, TX, USA, 2018;

Volume 10574, pp. 397–407.

6. Wegmayr, V.; Hörold, M.; Buhmann, J.M.

Generative aging of brain MR-images and

prediction of Alzheimer progression. In Pattern

Recognition: 41st DAGM German Conference,

DAGM GCPR 2019, Dortmund, Germany,

September 10–13, 2019, Proceedings 41; Springer:

Berlin/Heidelberg, Germany, 2019; pp. 247–260

7. Zhao, Y.; Ma, B.; Jiang, P.; Zeng, D.; Wang,

X.; Li, S. Prediction of Alzheimer’s disease

progression with multi-information generative

adversarial network. IEEE J. Biomed. Health

Inform. 2020, 25, 711–719. [Cross Ref]

8. Zhou, X.; Qiu, S.; Joshi, P.S.; Xue, C.; Killiany,

R.J.; Mian, A.Z.; Chin, S.P.; Au, R.; Kolachalama,

V.B. Enhancing magnetic resonance imagingdriven Alzheimer’s disease classification

performance using generative adversarial learning.

Alzheimer’s Res. Ther. 2021, 13, 497. [Cross Ref]

9. Logan, R.; Williams, B.G.; da Silva, M.F.;

Indani, A.; Schcolnicov, N.; Ganguly, A.; Miller,

S.J. Deep convolutional neural networks with ensemble learning and generative adversarial

networks for Alzheimer’s disease image data

classification. Front. Aging Neurosci. 2021, 13,

720226. [Cross Ref]

10. Zhang, J.; He, X.; Qing, L.; Gao, F.; Wang, B.

BPGAN: Brain PET synthesis from MRI using

generative adversarial network for multi-modal

Alzheimer’s disease diagnosis. Comput. Methods

Programs Biomed. 2022, 217, 106676. [Cross Ref]

11.Cabreza, J.N.; Solano, G.A.; Ojeda, S.A.;

Munar, V. Anomaly detection for Alzheimer’s

disease in brain MRIS via unsupervised generative

adversarial learning. In Proceedings of the 2022

International Conference on Artificial Intelligence

in Information and Communication (ICAIIC), Jeju

Island, Republic of Korea, 21–24 February 2022;

pp. 1–5.

12. Xia, T.; Sanchez, P.; Qin, C.; Tsaftaris, S.A.

Adversarial counterfactual augmentation:

Application in Alzheimer’s disease classification.

Front. Radiol. 2022, 2, 1039160. [Cross Ref]

13. Parisot, S.; Ktena, S.I.; Ferrante, E.; Lee, M.;

Guerrero, R.; Glocker, B.; Rueckert, D. Disease

prediction using graph convolutional networks:

Application to autism spectrum disorder and

Alzheimer’s disease. Med. Image Anal. 2018, 48,

117–130. [Cross Ref]

14. Zeng, L.; Li, H.; Xiao, T.; Shen, F.; Zhong, Z.

Graph convolutional network with sample and

feature weights for Alzheimer’s disease diagnosis.

Inf. Process. Manag. 2022, 59, 102952. [Cross Ref]

15. Ebrahimi-Ghahnavieh, A.; Luo, S.; Chiong, R.

Transfer learning for Alzheimer’s disease detection

on MRI images. In Proceedings of the 2019 IEEE

International Conference on Industry 4.0, Artificial

Intelligence, and Communications Technology

(IAICT), Bali, Indonesia, 1–3 July 2019; pp. 133–

138.

Published

2025-04-04

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Articles

How to Cite

Early Alzheimer’s Diagnosis Using Neural Networks. (2025). International Journal of Multidisciplinary Engineering In Current Research, 10(4), 49-58. https://ijmec.com/index.php/multidisciplinary/article/view/593