Formulation of a Nanocarrier System to Boost the Bioavailability of Abrus precatorius L

Abstract

The present investigation focuses on developing advanced nanocarrier systems to enhance the bioavailability of Abrus precatorius L. extracts. Traditional herbal formulations face significant challenges including poor solubility, rapid degradation, and limited absorption across biological barriers. This study introduces a comprehensive approach utilizing liposomal and polymeric nanocarriers to overcome these limitations. The methodology involved preparation of various nanocarrier formulations using different techniques including emulsification-solvent evaporation and thin-film hydration methods. Physicochemical characterization revealed optimal particle sizes ranging from 85-150 nm with encapsulation efficiency of 78-92%. In vitro dissolution studies demonstrated sustained release profiles over 24 hours. Pharmacokinetic studies in Wistar rats showed a remarkable 3.8-fold increase in bioavailability compared to conventional extracts. The nanocarrier formulations exhibited enhanced stability, controlled release kinetics, and improved therapeutic efficacy. Statistical analysis using ANOVA confirmed significant differences (p<0.001) between nanocarrier and conventional formulations. These findings demonstrate the potential of nanotechnology in revolutionizing the delivery of Abrus precatorius bioactive compounds for enhanced therapeutic applications.